In this strain, a neo cassette replaces exons 3-6 of the X-linked NADPH oxidase 1 (<i>Nox1</i>) gene, abolishing gene expression.  Homozygous females and hemizygous males are viable, fertile, and do not display any gross physical or behavioral abnormalities.  The NOX1 gene product, NADPH oxidase, is an enzyme highly expressed in colon epithelium; however it is also expressed in a large number of tissues including vascular smooth muscle cells, endothelial cells, uterus, placenta, prostate, osteoclasts, retinal pericytes and others.  NADPH oxidase regulates superoxide production in vascular tissues, influencing vasoconstriction, hypertension, and cellular and neuronal growth and apoptosis.  These NOX1-deficient mice exhibit a decrease in blood pressure, in proliferation of vascular smooth muscle, and in aortic media hypertrophy.  In response to Angiotensin II, a mediator of increased blood pressure and vascular disease, these mice show a reduction in sustained hypertension.

These <em>Nox1</em> knockout mice exhibit a decrease in blood pressure, in proliferation of vascular smooth muscle, and in aortic media hypertrophy. They may have applications in studies examining the role played by NADPH oxidase in vascular proliferation and vasoconstriction. 

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