129S6.Cg-Tg(RP23-472D11)7Mdf/Mmjax

Stock number: 018674
Product name: Tg(472D11)
Research areas: Research Tools

Description

The transgenic construct contains the BAC clone RP23-472D11, which includes the wild-type Sfxn1 gene. When combined with mice homozygous for Sfxn1^m1Mdf, mice are viable and fertile.

Detailed description

The transgenic construct contains the BAC clone RP23-472D11, which includes the wild-type Sfxn1 gene. When combined with mice homozygous for Sfxn1^m1Mdf, mice are viable and fertile.

Development

The transgenic construct contains the BAC clone RP23-472D11, which includes the wild-type Sfxn1 gene. The transgene was electroporated into 129S4/SvJae embryonic stem cells. Mice from founder line 7 were mated to 129S6.Cg-Sfxn1^m1Mdf mice. The donating investigator maintained the strain as a cross to 129S6.Cg-Sfxn1^m1Mdf at every generation. The transgene insertion site is unknown. Please Note: The MMRRC at The Jackson Laboratory is importing this strain without the Sfxn1 mutation.

Allele

Symbol: Tg(RP23-472D11)7Mdf
Name: transgene insertion 7, Mark D Fleming
MGI accession ID: MGI:5425685
Generation method: Transgenic
Attributes: Inserted expressed sequence; Humanized sequence
Marker symbol: Tg(RP23-472D11)7Mdf
Marker name: transgene insertion 7, Mark D Fleming
Chromosome: UN
Strain of origin: 129S4/SvJae
Expressed genes: SFXN1,sideroflexin 1,human
Molecular note: The transgene contains human bac BAC clone RP23-472D11. Line 7 was generated.