Mice homozygous for the Fcgrttm1Dcr and Prkdcscid alleles produce no mature T cells or B cells and have low serum levels of IgG and albumin. This strain may be used as a control for B6.Cg-Fcgrttm1Dcr Prkdcscid Tg(FCGRT)32Dcr/DcrJ (Stock No. 018441).
Dr. Derry Roopenian, The Jackson Laboratory
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Prkdc | protein kinase, DNA activated, catalytic polypeptide |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted (Null/Knockout) | Fcgrt | Fc receptor, IgG, alpha chain transporter |
Mice homozygous for the Fcgrttm1Dcr and Prkdcscid alleles produce no mature T cells or B cells and have low serum levels of IgG and albumin.
This strain may be used as a control for B6.Cg-Fcgrttm1Dcr Prkdcscid Tg(FCGRT)32Dcr/DcrJ (Stock No. 018441).
These mice were generated by crossing B6.129X1-Fcgrttm1Dcr/DcrJ mice (STOCK No. 003982) to B6.CB17-Prkdcscid/SzJ mice (STOCK No. 001913).
Allele Name | severe combined immunodeficiency |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | SCID |
Gene Symbol and Name | Prkdc, protein kinase, DNA activated, catalytic polypeptide |
Gene Synonym(s) | |
Site of Expression | T and B lymphocytes. |
Strain of Origin | C.BKa-Ighb/Icr |
Chromosome | 16 |
Molecular Note | A T-to-A transversion point mutation at a position corresponding to codon 4046 (codon 4095 in transcript ENSMUST00000023352.8) created a premature stop codon (p.Y4046*). |
Allele Name | targeted mutation 1, Derry C Roopenian |
---|---|
Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | FcRn- |
Gene Symbol and Name | Fcgrt, Fc receptor, IgG, alpha chain transporter |
Gene Synonym(s) | |
Strain of Origin | 129X1/SvJ |
Chromosome | 7 |
Molecular Note | Sequence from exon 1 and part of exon2 was replaced with a PGK-neo cassette. Quantitative PCR of liver cDNA indicated the absence of mRNA. Western blot analysis of neonatal intestinal extracts failed to reveal protein product. |
When maintaining a live colony, these mice can be bred as homozygotes.
When using the FcRn KO scid mouse strain in a publication, please cite the originating article(s) and include JAX stock #018541 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for Fcgrt<tm1Dcr>, Homozygous for Prkdc<scid> |
Frozen Mouse Embryo | B6.Cg-Fcgrt<tm1Dcr> Prkdc<scid>/DcrJ Embryos | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Fcgrt<tm1Dcr> Prkdc<scid>/DcrJ Embryos | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Fcgrt<tm1Dcr> Prkdc<scid>/DcrJ Embryos | $3373.50 |
Frozen Mouse Embryo | B6.Cg-Fcgrt<tm1Dcr> Prkdc<scid>/DcrJ Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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