Mice hemizygous for the BAC SNCA-Wt transgene are viable and fertile. These mice express a wild-type human synuclein, alpha (non A4 component of amyloid precursor), SNCA, gene directed by the human SNCA promoter/enhancer regions on the BAC transgene. The Donating Investigator reports that using qRT-PCR and Western Blot analysis, transgene expression is detected in the cortex and hippocampus, but not in kidney.

The Donating Investigator has not attempted to make this strain homozygous, and reports that preliminary data indicate that there is one copy of the transgene. Further characterization and verification of transgene expression is forthcoming.

These SNCA-Wt mice express a wild-type human synuclein, alpha (non A4 component of amyloid precursor), SNCA, gene directed by the human SNCA promoter/enhancer regions on the BAC transgene. These mice may be useful for studying SNCA function and the pathogenesis of Parkinson's disease.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.