Srsf1 (serine/arginine-rich splicing factor 1) is a serine/arginine (SR)-rich protein associated with the regulation of constitutive splicing. These targeted mutation mice carry a floxed allele of the gene. When crossed with a cre strain, tissue specific excision of exons 2-4 can be accomplished. Ubiquitous excision of the floxed segment is early embryonic lethal. Conditional knockout in cardiomyocytes with a Myl2-cre strain causes postnatal contraction defects and dilated cardiomyopathy. When bred to mice carrying Tg(Chx10-EGFP/cre,-ALPP)2Clc (see Stock No. <a href="https://www.jax.org/strain/005105">005105</a> for example) to direct cre recombinase expression to retina and Muller glial cells, this mutant mouse strain may be useful in studies of embryonic retinal development.

These floxed mutant mice possess loxP sites flanking exons 2-4 of the Srsf1 gene. This strain may be useful for generating conditional mutations in applications related to studies of embryonic retinal development.

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