Srsf1 (serine/arginine-rich splicing factor 1) is a serine/arginine (SR)-rich protein associated with the regulation of constitutive splicing. These targeted mutation mice carry a floxed allele of the gene. When crossed with a cre strain, tissue specific excision of exons 2-4 can be accomplished. Ubiquitous excision of the floxed segment is early embryonic lethal. Conditional knockout in cardiomyocytes with a Myl2-cre strain causes postnatal contraction defects and dilated cardiomyopathy. When bred to mice carrying Tg(Chx10-EGFP/cre,-ALPP)2Clc (see Stock No. <a href="https://www.jax.org/strain/005105">005105</a> for example) to direct cre recombinase expression to retina and Muller glial cells, this mutant mouse strain may be useful in studies of embryonic retinal development.

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These floxed mutant mice possess loxP sites flanking exons 2-4 of the Srsf1 gene. This strain may be useful for generating conditional mutations in applications related to studies of embryonic retinal development.

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