FKBP4 (or FKBP52) is a member of the immunophilin protein family and is known to play a role in protein folding and trafficking.  FKBP4 functions as a co-chaperone that binds to HSP90 in steroid receptor complexes. In this strain the targeted allele lacks the entire <i>Fkbp4</i> coding region. Homozygous mice are viable, but are not fertile.  Male mice exhibit mild to severe hypospadia, ambiguous external genitalia, malformed seminal vesicles and a small-to-absent anterior prostate gland.  Spermatozoa have reduced motility and fertilization efficiency. The donating investigator reports that homozygous females are infertile due to implantation failure. This strain may be useful for studying androgen, progesterone, and glucocorticoid receptor signaling pathways and reproduction.

These <i>Fkbp4</i> (or FKBP52) knockout mice are viable as homozygotes, but not fertile. They may have applications in studies related to androgen, progesterone, and glucocorticoid receptor signaling pathways and reproduction.


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