These double mutant mice produce human tau (MAPT) truncated at amino acid E391 and no endogenous mouse tau (Mapt). The low expressing E391-3608 transgenic mouse expresses the most abundant tau isoform found in the adult human brain, 4R1N, at 2.6 fold higher than normal endogenous mouse tau. Proteolytic cleavage of tau at the C-terminus is associated with neurofibrillary tangles and abnormal neurites in Alzheimer's Disease. The E391 mutant tau exhibits the pathologic phenotype - conformational change or hyperphosphorylation - in the superficial granule cells, cingulate gyrus, amygdala, and entorhinal cortex and to a lesser extent in the CA1 neuronal soma and apical dendrites. E391-3608 mice exhibit irregularly shaped pyramidal neurons with thickened dendrites in the cortex, and atypical dystrophic neurites in the cingulate gyrus. Despite the existence of "pretangle" tau pathology, mice do not develop late-stage neurofibrillary tangles. This mutant mouse strain may be useful in studies of tau in neurodegenerative disease.

These double mutant mice produce human tau (MAPT) truncated at amino acid E391 and no endogenous mouse tau (Mapt). E391-3608 mice exhibit irregularly shaped pyramidal neurons with thickened dendrites in the cortex, and atypical dystrophic neurites in the cingulate gyrus. Despite the existence of "pretangle" tau pathology, mice do not develop late-stage neurofibrillary tangles. This mutant mouse strain may be useful in studies of tau in neurodegenerative disease.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.