These transgenic mice express Cre recombinase under the control of the mouse Foxl1, forkhead box L1, promoter. Foxl1 is expressed in the stomach and intestine, and in oval cells in injured liver tissue. Oval cells are bipotential progenitor cells that differentiate into cholangiocytes and hepatocytes. Cre recombinase expression is detected in the mesenchymal cells of the stomach and intestine, and in cells of the liver portal triad after injury, mimicking the endogenous Foxl1 expression pattern. Mice hemizygous for the transgenic insert are viable and fertile. The Donating Investigator reports that homozygotes are not viable.

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Mice harboring the Foxl1-Cre transgene express Cre recombinase under the control of the mouse Foxl1, forkhead box L1, promoter, in the mesenchymal cells of the stomach and intestine, and in oval cells in injured liver. They may be useful for generating conditional mutations in gastrointestinal mesenchyme and liver progenitor cells.

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