hOC-GFPtpz transgenic mice express the topaz variant of green fluorescent protein (GFP) under the direction of the human bone gamma carboxyglutamate protein (BGLAP) promoter/enhancer sequence. The donating investigator reports that homozygotes are viable. BGLAP, also called osteocalcin, is expressed in bone and dentin and plays a role in bone building and mineralization and in calcium ion homeostasis. Under control of the BGLAP promoter, these mice express topaz protein in mature osteoblasts within well-developed bone nodules and in recently deposited bone matrix. Specifically, topaz was seen on the endosteal surface and in cortical bone at 7 days of age and within the mineralizing area of the bone nodule by 15 days of age. By 1 month of age, expression is seen in osteoblasts, osteocytes, and within vascular regions in cortical and trabecular bone.

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hOC-GFPtpz transgenic mice express the topaz variant of green fluorescent protein under the direction of the human BGLAP promoter/enhancer sequence. Expression is observed in mature osteoblasts of well-developed bone nodules and in recently deposited bone matrix.

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