Calcineurin is a calcium and calmodulin-dependent serine/threonine protein phosphatase that is known to play a variety of biological roles in various organ systems and processes including signal transduction, working memory, social behavior, and antigen-specific immune processes.

These tansgenic mice carry the Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform) C terminus autoinhibitory domain driven by the tetO promoter. When crossed with a tTA strain, transgene expression can be temporally regulated by doxycycline administration. The transgene does not appear to affect viability or fertility.

Neuronal expression of the transgene (e.g. via a Camk2a-tTA cross (see Stock No. 003010)) has multiple effects on synaptic plasticity and learning/memory behavior.

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TetO drives expression of the calcineurin (Ppp3ca, protein phosphatase 3, catalytic subunit, alpha isoform) autoinhibitory domain in these transgenic mice. When crossed with a tTA strain, transgene expression can be temporally regulated by doxycycline administration.

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B6.Cg-Tg(tetO-Ppp3ca*)13967Kndl/J Frozen Embryo