mThy1-hSNCA transgenic mice have the mouse thymus cell antigen 1 (Thy-1) promoter directing expression of the human &alpha;-synuclein (SNCA) gene. The transgene integrated into chromosome 14 causing a duplication in Slc4a7 (solute carrier family 4, sodium bicarbonate cotransporter, member 7). The duplication results in a functional knock-out of Slc4a7 in homozygous mice. Hemizygotes are viable, fertile, and normal in size. This line carries ~23 copies of the transgene; expression is relatively high in the cerebral cortex and hippocampus, and relatively low in the kidneys. These mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration elicited by the toxic effects of aggregation and somatic accumulation of SNCA. 

There is a different founder line with the same construct available,
<a href=http://jaxmice.jax.org/strain/017682.html>stock number 17682</a>, which has about 2-fold higher expression of the transgenic protein in the striatum and cortex.

mThy1-hSNCA mice contain a transgene consisting of the mouse thymus cell antigen 1 (Thy-1) promoter directing expression of the human &alpha;-synuclein (SNCA) gene. These mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration elicited by the toxic effects of aggregation and somatic accumulation of SNCA.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

Typically mice are recovered in 12-16 weeks. <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> to place an order or for more information.