The Alb1-cre transgene was designed with a Cre recombinase gene under control of Alb promoter/enhancer elements. These mice may be useful for studying the liver specific deletion of target genes.
Dr. Derek LeRoith, Mount Sinai School of Medicine
Genetic Background | Generation |
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Allele Type |
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Transgenic (Recombinase-expressing) |
The Alb1-cre transgene was designed with a Cre recombinase gene under control of albumin (Alb) promoter/enhancer elements. Hemizygous Alb1-cre mice are viable, fertile, and normal in size, with cre expression directed specifically to the liver. When these transgenic mice are bred with mice containing a loxP-flanked sequence, Cre-mediated recombination is expected to result in deletion of the floxed sequences in the Cre recombinase-expressing hepatic cells of the offspring. For example, when these mice are bred to Igf1tm1Dlr-containing mice (Stock No. 012663 or Stock No. 016831), the removal of IGF1 expression in the liver causes a 75% reduction in serum IGF-1levels. These mice may be useful for studying the liver specific deletion of target genes.
The Alb1-Cre transgene was designed with a Cre recombinase gene under control of albumin (Alb) promoter/enhancer elements. The construct was microinjected into fertilized FVB/N oocytes, and founder mice were bred to FVB/NJ mice. The resulting mice were then crossed to B6.129-Igf1tm1Dlr mice. The resulting offspring were then backcrossed to an C57BL/6J for at least 9 generations. Upon arrival, the mice were bred to C57BL/6J inbred mice (Stock No. 000664) for one generation and floxed allele was selectively bred out of the line.
Expressed Gene | cre, cre recombinase, bacteriophage P1 |
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Site of Expression | liver |
Allele Name | transgene insertion 1, Derek LeRoith |
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Allele Type | Transgenic (Recombinase-expressing) |
Allele Synonym(s) | AlbCre; Alb-cre; Albumen-Cre; Albumin-Cre |
Gene Symbol and Name | Tg(Alb1-cre)1Dlr, transgene insertion 1, Derek LeRoith |
Gene Synonym(s) | |
Promoter | Alb, albumin, mouse, laboratory |
Expressed Gene | cre, cre recombinase, bacteriophage P1 |
Site of Expression | liver |
Strain of Origin | FVB/N |
Chromosome | UN |
Molecular Note | This transgene expresses Cre recombinase in the liver, under the control of an albumin promoter (species not specified). |
Mutations Made By | Dr. Derek LeRoith, Mount Sinai School of Medicine |
When maintaining a live colony, homozygous mice may be bred together.
When using the Alb1-cre mouse strain in a publication, please cite the originating article(s) and include JAX stock #016832 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous or non Carrier for Tg(Alb1-cre)1Dlr |
Frozen Mouse Embryo | B6.FVB(129)-Tg(Alb1-cre)1Dlr/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.FVB(129)-Tg(Alb1-cre)1Dlr/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.FVB(129)-Tg(Alb1-cre)1Dlr/J Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | B6.FVB(129)-Tg(Alb1-cre)1Dlr/J Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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