Homozygotes: Mice that are homozygous for this chemically induced mutation are sterile. Females exhibit ovarian dsygenesis and lack ovarian follicles at reproductive maturity. Testes in affected males are about 50% smaller than wild-type at 5-6 weeks of age due to arrest of spermatogenesis during meiotic prophase I. No postmeiotic spermatids are observed in the seminiferous tubules of 5 week old mice. The underlying cause for arrest in both sexes is failure to repair Spo11-induced meiotic double strand breaks, plus improper synapsis.This mutant mouse strain may be useful in studies of meiosis, synaptonemal complex assembly, double strand break repair and sister chromatid cohesion.

Heterozygote: 
Heterozygote phenotype is expected to be similar to wildtype phenotype.

These EMS-induced mice are sterile; females exhibit ovarian dsygenesis and lack ovarian follicles. Males have small testes and lack postmeiotic spermatids. This mutant mouse strain may be useful in studies of meiosis, synaptonemal complex assembly, double strand break repair and sister chromatid cohesion.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.