C57BL/6J-Rnl16/BPgn

Stock number: 016255
Product name: renal 16
Research areas: Internal/Organ Research

Description

These mice show increased blood urea nitrogen (BUN) levels and may be useful in studies of kidney function.

Detailed description

Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Screening of third generation mice (G3) on standard chow identified a 20 week old male with an increased blood urea nitrogen (BUN) of 34 mg/dL. Testing one week later confirmed the increased BUN value (34 mg/dL). This mutant mouse strain may be useful in studies of kidney function.

Development

This phenotypic deviant was identified following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664), in complex heart, lung, blood, and sleep disorders at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory. In the F2 and F3 generations, some animals exhibited increased albumin/creatinine ratios (ACR) in addition to increased BUN levels. In succeeding generations, mice with elevated BUN were bred away from mice with elevated ACR to establish the "B" line.

Allele

Symbol: Rnl16
Name: renal 16
MGI accession ID: MGI:4843946
Generation method: Chemically induced (ENU)
Marker symbol: Rnl16
Marker name: renal 16
Chromosome: 1
Strain of origin: C57BL/6J
Molecular note: This mutant was identified in an ENU mutagenesis screen. The mutation has been mapped to chromosome 1.