Full-length mouse Cry2 (cryptochrome 2 (photolyase-like)) cDNA is the under transcriptional control of a tetracycline-responsive promoter in these transgenic mice. When crossed with animals expressing the tetracycline-controlled transactivator (tTA) or reverse tetracycline-controlled transactivator (rtTA) protein under the control of tissue-specific promoters, transgene expression can be regulated in the offspring by the administration of doxycycline. 

When crossed with an Scg2 (secretogranin II)-promoter driven tTA strain (see Stock No. <a href="https://www.jax.org/strain/008284">008284</a>), CRY2 is expressed in the suprachiasmatic nucleus and brain, causing a circadian pattern with a shortened period. This effect can be inhibited by low doses of doxycycline in the drinking water. The effects of low, but not high, doses of doxycycline are completely reversible and lead to a rapid reactivation of the transgene.

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Full-length mouse Cry2 (cryptochrome 2 (photolyase-like)) cDNA is under the transcriptional control of a tetracycline-responsive promoter in these transgenic mice. This strain may be useful in studies of circadian rhythm.

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