Mice homozygous for this Atp2b2 (ATPase, Ca++ transporting, plasma membrane 2) mutation show severe ataxia. Both homozygotes and heterozygotes have a hearing defect.
Dr. Joseph S. Takahashi, Univ Texas Southwestern Medical Ctr
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Atp2b2 | ATPase, Ca++ transporting, plasma membrane 2 |
Exon 12 was spontaneously deleted in these Atp2b2 (ATPase, Ca++ transporting, plasma membrane 2) mutant mice, creating a premature stop codon. Homozygotes show severe ataxia that is evident from approximately postnatal day 14 (P14). Both homozygotes and heterozygotes have a hearing defect.
A spontaneous deletion of exon 12 resulted in a frameshift that created a premature stop codon. The mutation arose on a C3B6F2 hybrid background. This strain was backcrossed to C57BL/6 for 10 generations by the donating laboratory.
Allele Name | lilop |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Atp2b2, ATPase, Ca++ transporting, plasma membrane 2 |
Gene Synonym(s) | |
Strain of Origin | (C3H x C57BL/6)F2 |
Chromosome | 6 |
Molecular Note | A spontaneous deletion of exon 12 resulted in a frameshift that created a premature stop codon. |
When maintained as a live colony, heterozygotes may be bred. Homozygotes develop severe ataxia at about 2 weeks of age.
When using the B6.Cg-Atp2b2lilo/JtJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #016172 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or wildtype for Atp2b2<Lilo> |
Frozen Mouse Embryo | B6.Cg-Atp2b2<lilo>/JtJ | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Atp2b2<lilo>/JtJ | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Atp2b2<lilo>/JtJ | $3373.50 |
Frozen Mouse Embryo | B6.Cg-Atp2b2<lilo>/JtJ | $3373.50 |
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