This NOD/MrkTac congenic strain, commonly referred to as NOD.B10-Idd9.4, line 9142 contains a 2Mb genomic segment from the diabetes resistant strain C57BL/10SnJ (Stock No. <a href="https://www.jax.org/strain/000666">000666</a>) introgressed into chromosome 4 and is defined within markers D4Dil31 (87Mb) and D4Dil43 (88.5Mb). The C57BL/10SnJ genomic segment includes an interferon gene cluster thought to be involved with autoimmunity. The donating investigator indicates that homozygous congenic females exhibit significantly diminished diabetes development compared to NOD/MrkTac controls. 
This strain may be useful for positional mapping of the Idd9.4 loci and studying interferon candidate genes affecting autoimmunity.

This chromosome 4 congenic stock contains the C57BL/10SnJ derived interferon gene cluster, IFN, (Idd9.4) introgressed into the NOD/MrkTac background and exhibits significantly reduced diabetes incidence. This strain may be useful for positional mapping of the Idd9.4 loci and studying interferon candidate genes affecting autoimmunity.

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