Mice homozygotes for the recessive spontaneous mutation pinwheel display moderate bidirectional circling and difficulty orienting in water to swim, indicative of a vestibular defect. However, auditory brainstem response analysis did not detect any hearing loss relative to age-matched controls. This heritable phenotype has been mapped to an interval between D4Mit170 and D4Mit33.
The pinwheel mutation arose spontaneously in the B6SJL-Tg(SOD1*G93A)1Gur/J strain (stock#002726) at The Jackson Laboratory in 1995. It was backcrossed onto C57BL/6J until N7, thereby removing the transgene from this mutant subline. This strain was then maintained by sibling intercrossing heterozygous females with homozygous males and sperm was cryopreserved from homozygous males at generation N7F10.
|Allele Type||Spontaneous (Not Specified)|
|Gene Symbol and Name||pwhl, pinwheel|
|Strain of Origin||B6SJL-Tg(SOD1*G93A)1Gur/J|
|Molecular Note||This spontaneous phenotypic mutation has been mapped to an interval between D4Mit170 and D4Mit33, but the molecular lesion has not yet been identified.|
Because the circling of the homozygote can interfere with the rearing of the pups it is best to remove the homozygous male before birth.
When using the B6.Cg-pwhl/KjnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #016124 in your Materials and Methods section.