These Delta RG transgenic mice express a dominant negative mutant mouse <i>Tsc2</i> (tuberous sclerosis 2) gene that lacks the sequence encoding the rabaptin-5 and rap1GAP motifs. Expression is directed by the CMV, cytomegalovirus, promoter. TSC2 is a putative tumor supressor. Mutation of TSC2 have been associated with the onset of tuberous sclerosis complex (TSC) which is characterized by the formation of non-malignant tumors in many different organs.
Mice that are hemizygous for the transgene are viable and fertile. They develop skin and brain hamartomas with aggregates of granular cells at the surface cerebellum (subpial) and collagenous fibrovascular proliferations containing abundant mast cells in the skin.  Hemizygotes exhibit higher anxiety, spending less time in the open arms of an elevated plus maze when compared to wildtype mice. Mild learning and memory defects are also observed.  

 

This Tsc2-DN transgenic mouse strain expresses a dominant negative mutant mouse <i>Tsc2</i> (tuberous sclerosis 2) may be useful in studies of tuberous sclerosis.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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