Homozygous mutants exhibit skeletal deformities and hearing loss.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Fgfr3 | fibroblast growth factor receptor 3 |
Mice homozygous for the recessive Fgfr3m1J allele have skeletal deformities that result in kyphosis, scoliosis, and a bent tail, which is often found to exit the pelvis at an abnormal angle. ABR threshold assessment shows hearing loss to the point of deafness at 3 to 4 weeks of age, the earliest age assessed. Male homozygotes display infertility, but females do breed and rear pups. Homozygotes have not been found to have a reduced lifespan, distinct from the reduced lifespan or prenatal lethality found in homozygotes for targeted deletions of this gene.
This mutation arose spontaneously in the CByJ.A-Atp2b2dfw-2J/J strain in 2003 when the flaky skin mutation might still have been segregating in the background. The mutant subline has been maintained by sibling inbreeding and the deaf waddler 2 Jackson mutation has been selectively bred out. No mice with the flaky skin phenotype have ever been detected in this mutant subline.
Allele Name | mutation 1, Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Fgfr3, fibroblast growth factor receptor 3 |
Gene Synonym(s) | |
Strain of Origin | CByJ.A-Atp2b2dfw-2J/J |
Chromosome | 5 |
Molecular Note | A failed complementation test with Fgfr3tm1Dor demonstrated that this mutation is an allele of Fgfr3. |
When using the CByJ.Cg-Fgfr3m1J/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #014182 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Fgfr3<m1J> |
Frozen Mouse Embryo | CByJ.Cg-Fgfr3<m1J>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | CByJ.Cg-Fgfr3<m1J>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | CByJ.Cg-Fgfr3<m1J>/GrsrJ | $3373.50 |
Frozen Mouse Embryo | CByJ.Cg-Fgfr3<m1J>/GrsrJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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