This NOD congenic strain, commonly referred to as NOD.Cd45.2, is viable and fertile. Mice of this strain contain a genomic segment from the diabetes resistant strain C57BL/6 introgressed into the NOD chromosome 1. The C57BL/6 genomic segment includes Ptprcb, commonly referred to as Cd45.2. Although reported to be significantly reduced compared to NOD, congenic female mice exhibit a high frequency of diabetes with about 60% of the females becoming diabetic by 200 days of age. 
As Ptprc is expressed on all adaptive and innate immune cells, this strain provides a unique cell surface marker that can be used to track lineage and phenotype of all hematopoietic donor derived or transferred cells making it useful in studies monitoring immune pathogenesis in the NOD model.

This NOD congenic strain contains Ptprc of C57BL/6J origin (CD45.2) and is reported to exhibit a high frequency of diabetes. As Ptprc is expressed on all adaptive and innate immune cells, this strain provides a unique cell surface marker that can be used to track lineage and phenotype of all hematopoietic donor derived or transferred cells making it useful in studies monitoring immune pathogenesis in the NOD model.&nbsp;

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