This strain, carrying undefined mutations b2b904.1Clo and b2b904.2Clo, was identified in an ENU screen for recessive cardiovascular development phenotypes in Dr. Cecilia Lo's laboratory, NHLBI Cardiovascular Development Consortium (CvDC). It was recovered from G1 sperm and associated with the phenotype described here. Because G1 sperm were cryopreserved, additional incidental mutations are also segregating in this strain.
Homozygotes of mutant type 1 demonstrate right ventricular myocardial noncompaction and a dilated ventricular chamber. Mutant type 2 animals show ventricular hypertrophy.