This line carries a Cre transgene under the control of the adenovirus EIIa promoter that targets expression of Cre recombinase to the early mouse embryo. Cre expression is thought to occur prior to implantation in the uterine wall. A mosaic pattern of expression is commonly observed. Cre-mediated recombination occurs in a wide range of tissues, including the germ cells that transmit the genetic alteration to progeny.

<a href="http://www.informatics.jax.org/allele/MGI:2137691?recomRibbon=open">View</a> cre expression characterization on the FVB background.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

These EIIa-Cre transgenic mice express Cre recombinase under the control of the adenovirus EIIa promoter. When crossed with a strain containing loxP site-flanked sequences, Cre-mediated recombination occurs in a wide range of tissues, including germ cells that transmit the genetic alteration to progeny.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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