Homozygous <i>Asic2</i> (amiloride-sensitive cation channel 1, neuronal (degenerin)) targeted mutation mice display subtle alterations in mechanoreceptor and spiral ganglion function, and are more sensitive to light-induced retinal degeneration. Transcripts and protein are missing for both spliced forms of the gene, as determined by Western and Northern blot analysis of mouse brain. Homozygous mice show a reduced reproductive capacity that is reportedly 25% that of wild-type mice. This strain may be helpful in studies of touch sensation.

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Homozygous <i>Asic2</i> knockout mice display subtle alterations in mechanoreceptor and spiral ganglion function, and are more sensitive to light-induced retinal degeneration. This strain may be helpful in studies of touch sensation.

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