Mutant mice exhibit neurodevelopmental defects leading to short, curly tails and spina bifida.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Vangl2 | VANGL planar cell polarity 2 |
The loop tail like mutation is similar to the loop tail mutation of the Vangl2 gene in causing neurodevelopmental defects leading to short, curly tails and spina bifida. There is incomplete penetrance and prenatal and perinatal lethality. Some heterozygous with mild spina bifida survive to adulthood and have bred. Some heterozygous females have closed vaginas.
The looptail-like mutation arose spontaneously in the strain B6.129S7-Gt(ROSA)26Sor/J (stock #002192) at The Jackson Laboratory in the year 2000 and the Gt(ROSA)26Sor has been bred out of this mutant subline via backcross-intercross to C57BL/6J.
Allele Name | loop tail 2 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | Lootl |
Gene Symbol and Name | Vangl2, VANGL planar cell polarity 2 |
Gene Synonym(s) | |
Strain of Origin | B6.129S7-Gt(ROSA)26Sor/J |
Chromosome | 1 |
Molecular Note | This spontaneous mutation is an A-to-G (T-to-C on forward strand) substitution in the 5' UTR. |
When using the loop tail-like mouse strain in a publication, please cite the originating article(s) and include JAX stock #013121 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Lootl |
Frozen Mouse Embryo | B6.Cg-Vangl2<Lp-2J>/GrsrJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Vangl2<Lp-2J>/GrsrJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Vangl2<Lp-2J>/GrsrJ Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | B6.Cg-Vangl2<Lp-2J>/GrsrJ Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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