Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.  Isolated T cells exhibit increased proliferation with activation.  Th1 cells from homozygotes are more resistant to activation induced apoptosis.  10 month old homozygotes exhibit mild splenomegaly.  Homozygotes are more susceptible to experimental autoimmune encephalomyelitis, with longer duration and severity: 60% of homozygotes die when challenged with a higher dose of heat-inactivated <i>Mycobacterium tuberculosis</i>, compared to no deaths in controls.  Immunocomplex deposits develop in the glomeruli of homozygotes.

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This <i> Gadd45b</i> targeted mutation strain may be useful in studies of autoimmune disease.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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