Homozygous Inpp (inositol polyphosphate-1-phosphatase) targeted mutation mice are viable and fertile and have no observable phenotype or physical abnormalities. Although it is unknown whether aberrant transcripts are expressed, the catalytic residues have been eliminated, thus preventing all enzymatic activity. This strain may be useful for further characterization of the targeted gene.
John York, Duke University Medical Center
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted (Null/Knockout) | Inpp1 | inositol polyphosphate-1-phosphatase |
Homozygous Inpp (inositol polyphosphate-1-phosphatase) targeted mutation mice are viable and fertile and have no observable phenotype or physical abnormalities. Although it is unknown whether aberrant transcripts are expressed, the catalytic residues have been eliminated, thus preventing all enzymatic activity. This strain may be useful for further characterization of the targeted gene.
Exons 4 and 5, encoding the catalytic residues were replaced with a neomycin resistance cassette in (129X1/SvJ x 129S1/Sv)F1- Kitl+-derived R1 embryonic stem (ES) cells. This strain was maintained on a mixed C57BL/6 and 129 genetic background by the donating laboratory.
Allele Name | targeted mutation 1, John D York |
---|---|
Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | 1 Ptase (founder 3) |
Gene Symbol and Name | Inpp1, inositol polyphosphate-1-phosphatase |
Gene Synonym(s) | |
Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl+ |
Chromosome | 1 |
Molecular Note | Exons 4 and 5, encoding the catalytic residues, were replaced with a neomycin resistance cassette. |
Mutations Made By | John York, Duke University Medical Center |
When maintained as a live colony, homozygotes or heterozygotes may be bred.
When using the B6;129-Inpp1tm1Yrk/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #012917 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Inpp1<tm1Yrk> |
Frozen Mouse Embryo | B6;129-Inpp1<tm1Yrk>/J | $2595.00 |
Frozen Mouse Embryo | B6;129-Inpp1<tm1Yrk>/J | $2595.00 |
Frozen Mouse Embryo | B6;129-Inpp1<tm1Yrk>/J | $3373.50 |
Frozen Mouse Embryo | B6;129-Inpp1<tm1Yrk>/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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