Mice hemizygous for the ePet-Cre transgene are viable and fertile, with the FEV (ePet or Pet1 ETS oncogene family) promoter sequence directing expression of Cre recombinase in all mid-hindbrain serotonin (5HT)-synthesizing neurons and their postmitotic precursors. When these transgenic mice are bred with mice containing a loxP-flanked sequence, Cre-mediated recombination is expected to result in deletion of the floxed sequences in the Cre recombinase-expressing tissues of the offspring. These mice may be useful for inducing cre-mediated recombination in serotonergic neurons.

Use of MICE by companies or for-profit entities requires a license prior to shipping.

This strain ships with remnant UID MiniMax microchips implanted 
subcutaneously in the back. For more information on these RFID chips, 
including our FAQ, please visit our <a href="https://www.jax.org/jax-mice-and-services/customer-support/technical-support/breeding-and-husbandry-support/mouse-identification">Mouse Identification page</a>.These mice express cre under the direction of the Fev promoter. They may be useful for inducing cre-mediated recombination in serotonergic neurons.

Live mice available in varying quantities. <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for specifics.