Mice that are homozygous for both targeted alleles are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.  Mice exhibit defects in lymphocyte activation.  This mutant mouse strain may be useful in studies of T cell regulation, activation and tolerance.

These targeted mutant mice possess insertions in the IgV exons of Pdcd1lg2 (programmed cell death 1 ligand 2) and Cd274, which affects lymphocyte activation and may be useful in studies of T cell regulation, activation and tolerance.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.