In this strain, exons 1-2 of the endogenous mouse immediate early response 3 (Ier3) gene is replaced with a neo cassette, abolishing gene function. Homozygotes are viable, fertile, and normal in size. These mice develop elevated blood pressure, cardiac hypertrophy, and increased heart rate. No differences were found in the immune cells of the spleen, subcutaneous and mesenteric lymph nodes, thymus, or bone marrow of the gly96/IEX-1-/- mice compared to wild-type. These mice may be useful for studying hypertension, cardiac hypertrophy, and cardiovascular physiology and disease.
