Mice homozygous for the targeted mutation are viable and fertile. Homozygous mutant mice show no overt phenotypic abnormalities. When used in conjunction with a Cre recombinase-expressing strain, this strain is useful in generating tissue-specific mutants of the floxed allele. Excision of the floxed fragment in intestines and treatment with benzopyrene (BaP) results in immunosuppression and shortened lifespan. This mutant strain is useful in organ specific studies involving aryl hydrocarbon (AHR) ligands, immunosuppression and metabolism of polycyclic aromatic hydrocarbon (PAH).

These mutant mice possess loxP sites flanking an HPRT minigene in intron 1 of the Cyp1a1 (cytochrome P450)gene and may be useful in organ specific studies involving aryl hydrocarbon (AHR) ligands, immunosuppression and metabolism of polycyclic aromatic hydrocarbon (PAH).

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.