Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Mast cell response (degranulation, cytokine expression) to stimulation of the IgE receptor FceR1 is impaired and results in a diminished allergic response. Passive cutaneous and systemic anaphylaxis is significantly reduced in these mice. Mast cell numbers are reduced in back and thigh skin and undetectable in the peritoneum.

This mutant mouse strain may be useful in studies of allergic reactions and anaphylaxis.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

These Gab2 knockout mice exhibit an impaired mast cell response (degranulation, cytokine expression), a diminished allergic response, reduced mast cell numbers and reduced passive cutaneous and systemic anaphylaxis. This mutant mouse strain may be useful in studies of allergic reactions and anaphylaxis.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.