Mice that are heterozygous for the targeted mutation are viable, fertile, and normal in size. Heterozygous mice have posterior cerebellar hypoplasia and mild anterior foliation defects. Retinogeniculate projections from the lateral geniculate nucleus exhibit an altered topographic patterning. Homozygous mice are viable and fertile.
This mutant mouse strain may be useful in studies of cerebellar development and Dandy-Walker malformation.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

This targeted mutation of Zic4 gene displays cerebellar hypoplasia and mild foliation defects. This strain may be useful in the study of cerebellar development and Dandy-Walker malformation.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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