These transgenic mice express Cre recombinase under the direction of the mouse <i>Nr5a1</i>, nuclear receptor subfamily 5, group A, member 1, promoter. The Cre recombinase activity pattern mimics the endogenous gene expression (mRNA) pattern.  Cre mediated recombination is detected in steroidogenic factor-1 (SF1)-positive neurons in the ventromedial hypothalamic nucleus (VMH) as well as pituitary, gonad, and adrenal tissue.  Mice hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.  The Donating Investigator has not attempted to make the strain homozygous.  When crossed with a strain containing <i>loxP</i> site flanked sequence, Cre-mediated recombination results in tissue-specific deletion of the flanked sequence in the offspring.

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 SF1-Cre transgenic mice have Cre recombinase expression detected in steroidogenic factor-1 (SF1)-positive neurons in the ventromedial hypothalamic nucleus as well as pituitary, gonad, and adrenal tissue. These mice may be useful for generating tissue specific-targeted mutants for studies of the subset of SF1-positive neurons, obesity, metabolic and energy homeostasis, and appetite control/satiety.

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