This congenic expresses the C57BL/6J derived sequence of Fscn2, rather than the Fscn2ahl8 sequence, and has a resulting amelioration of the early onset hearing loss characteristic in DBA/2J mice. This congenic rescue is similar to that found in the transgenic rescue in DBA/2J-Tg(RP24-180N9)2Kjn/Kjn (stock #012440).
Dr. Ken Johnson, JAX
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Not Applicable | Fscn2 | fascin actin-bundling protein 2 |
This congenic expresses the C57BL/6J derived sequence of Fscn2, rather than the Fscn2ahl8 sequence, and has a resulting amelioration of the early onset hearing loss characteristic in DBA/2J mice. Distinct from the DBA/2J host background these congenic mice have click, 8 kHz, and 16 kHz ABR thresholds at 2 months of age that are equivalent to those of C57BL/6J, although the 32 kHz thresholds are elevated similar to those of DBA/2J. This congenic rescue is similar to that found in the transgenic rescue in DBA/2J-Tg(RP24-180N9)2Kjn/Kjn (stock #012440).
This congenic was generated by repeatedly backcrossing the Fscn sequence from C57BL/6J onto DBA/2J until generation N10 and then intercrossing to make the C57BL/6J-derived interval homozygous on the DBA/2J background.
When using the D2.B6-Fscn2+/Kjn mouse strain in a publication, please cite the originating article(s) and include JAX stock #012438 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Fscn2<+> |
Frozen Mouse Embryo | D2.B6-Fscn2<+>/Kjn | $2595.00 |
Frozen Mouse Embryo | D2.B6-Fscn2<+>/Kjn | $2595.00 |
Frozen Mouse Embryo | D2.B6-Fscn2<+>/Kjn | $3373.50 |
Frozen Mouse Embryo | D2.B6-Fscn2<+>/Kjn | $3373.50 |
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