B6.NOD-tth^2J/KjnJ

Stock number: 012306
Product name: tremor with tilted head(2J)
Research areas: Neurobiology Research

Description

These mice harbor a recessive mutation causing a tilted head, tremor, circling, and failed swim test.

Detailed description

Homozygotes can be identified by a tilted head and tremor in the gait by 4 weeks of age. Some display circling behavior. They are unable to orient in water, but a severe hearing deficit has not been detected.

Development

This spontaneous mutation arose in the strain NOD/ShiLtDvs-Tg(Ins2-E3*734)3Dvs/Dvs (stock #004968) in 2004 and was backcrossed onto the C57BL/6J background, selecting away from the transgene. In 2010 sperm was cryopreserved from homozygous males at generation N8F4.

Allele

Symbol: tth^2J
Name: tremor with tilted head 2 Jackson
MGI accession ID: MGI:4415267
Generation method: Spontaneous
Marker symbol: tth
Marker name: tremor with tilted head
Chromosome: 15
Strain of origin: NOD/ShiLtDvs-Tg(Ins2-E3*734)3Dvs/DvsJ
Molecular note: A failed complementation tests with the original tremor with tilted head mutation proved them allelic.