Homozygotes can be identified by a tilted head and tremor in the gait by 4 weeks of age. Some display circling behavior. They are unable to orient in water, but a severe hearing deficit has not been detected.
This spontaneous mutation arose in the strain NOD/ShiLtDvs-Tg(Ins2-E3*734)3Dvs/Dvs (stock #004968) in 2004 and was backcrossed onto the C57BL/6J background, selecting away from the transgene. In 2010 sperm was cryopreserved from homozygous males at generation N8F4.
|Allele Name||tremor with tilted head 2 Jackson|
|Gene Symbol and Name||tth, tremor with tilted head|
|Strain of Origin||NOD/ShiLtDvs-Tg(Ins2-E3*734)3Dvs/DvsJ|
|Molecular Note||A failed complementation tests with the original tremor with tilted head mutation proved them allelic.|