These mice possess loxP sites on either side of exon 3 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 3 deleted in the cre-expressing tissue(s).
When crossed with a mouse overexpressing constitutively active Kras and expressing mammary gland specific Cre recombinase, this IGF1RLox mutant mouse strain may be useful in studies of mammary tumorigenesis (Proc Natl Acad Sci U S A 2009 Feb 17;106(7):2359-64).
When bred to a strain with Cre recombinase expression in the CNS, this mutant mouse strain may be useful in studies of myelination (Genesis 2000 Feb;26(2):133-5).
When bred to a strain carrying Tg(BGLAP-cre)1Clem (Stock No. 019509), Cre recombinase expression in osteoblasts results in abnormal bone matrix mineralization (J Biol Chem 2002 Nov 15;277(46):44005-12).
When bred to a strain carrying Tg(Tek-cre)1Ywa (Stock No. 008863), Cre recombinase expression in endothelial cells results in impaired endothelial regeneration following arterial injury.
