JAX
Mouse Strain Datasheet - 012237
B6.Cg-Tg(Cdh16-cre)91Igr/J
Also Known As: Ksp-Cre, Ksp1.3/Cre
These Ksp1.3/Cre transgenic mice express Cre recombinase under the control of the mouse cadherin 16 (Cdh16 or Ksp1.3) promoter. Cre recombinase expression is detected in epithelial cells of the developing kidney and genitourinary tract and in the renal tubules of adult mice. This mutant mouse strain may be useful in kidney-specific gene targeting and cell lineage studies.
Donating Investigator
Peter Igarashi, UT Southwestern Medical Center at Dallas
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N21+pN2F2
|
Tg(Cdh16-cre)91Igr
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Base Price
Starting at:
| $263.00 Domestic price for female |
| $337.00 Domestic price for breeder pair |
Detailed Description
Hemizygous and homozygous mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. These Ksp1.3/Cre transgenic mice express Cre recombinase under the control of the mouse cadherin 16 (Cdh16 or Ksp-cadherin) promoter. Cre recombinase expression follows expression of the endogenous gene and is detected in the epithelial cells of developing nephrons, ureteric bud, mesonephric tubules, Wolffian duct, and Mullerian duct. In the adult mouse expression is limited to the renal tubules especially the collecting ducts, loops of Henle and distal tubules. When crossed with a strain containing loxP site flanked sequence, Cre-mediated recombination results in deletion of the flanked sequence in the offspring. This mutant mouse strain may be useful in kidney-specific gene targeting and cell lineage studies.
Development
A transgenic construct containing sequence encoding Cre recombinase under the control of the mouse cadherin 16 (Cdh16 or Ksp-cadherin) promoter was introduced into ICR fertilized mouse eggs. Founder line 91 was subsequently established and crossed to a C57BL/6 (see SNP note below) for more than 20 generations by the donating laboratory.
A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 4 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a C57BL/6N genetic background.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | Cdh16 promoter drives transgene expression in the developing kidney and genitourinary tract. |
Control Suggestions
Selected References
- Shao X; Somlo S; Igarashi P. 2002. Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract. J Am Soc Nephrol 13(7):1837-46. PubMed: 12089379MGI: J:82531
Tg(Cdh16-cre)91Igr
Allele Symbol: Tg(Cdh16-cre)91Igr
| Allele Name | transgene insertion 91, Peter Igarashi |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | Ksp Cre; Ksp-Cre; Ksp1.3-Cre; Ksp1.3/Cre; KspCre |
| Gene Symbol and Name | Tg(Cdh16-cre)91Igr, transgene insertion 91, Peter Igarashi |
| Gene Synonym(s) | Ksp-Cre; Ksp1.3-Cre; Ksp1.3/Cre; KspCre |
| Promoter | Cdh16, cadherin 16, mouse, laboratory |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | Cdh16 promoter drives transgene expression in the developing kidney and genitourinary tract. |
| Strain of Origin | ICR |
| Chromosome | UN |
| General Note | This transgenic line is also representative of the cre expression pattern in line 38. |
| Molecular Note | The transgene consists of 1341 bp of the Cdh16 5' flanking region, a beta-globin minimal promoter, and a cre recombinase sequence. The Cdh16 promoter was used to drive transgene expression in the developing kidney and genitourinary tract. |
| Mutations Made By | Peter Igarashi, UT Southwestern Medical Center at Dallas |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Developmental Biology Research
- Cre-lox System
- Reproductive Biology Research
- Cre-lox System
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
References
- Shao X; Somlo S; Igarashi P. 2002. Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract. J Am Soc Nephrol 13(7):1837-46. PubMed: 12089379MGI: J:82531
Additional - Tg(Cdh16-cre)91Igr related
- Adam J; Hatipoglu E; O'Flaherty L; Ternette N; Sahgal N; Lockstone H; Baban D; Nye E; Stamp GW; Wolhuter K; Stevens M; Fischer R; Carmeliet P; Maxwell PH; Pugh CW; Frizzell N; Soga T; Kessler BM; El-Bahrawy M; Ratcliffe PJ; Pollard PJ. 2011. Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling. Cancer Cell 20(4):524-37. PubMed: 22014577MGI: J:177485
- Adam J; Yang M; Bauerschmidt C; Kitagawa M; O'Flaherty L; Maheswaran P; Ozkan G; Sahgal N; Baban D; Kato K; Saito K; Iino K; Igarashi K; Stratford M; Pugh C; Tennant DA; Ludwig C; Davies B; Ratcliffe PJ; El-Bahrawy M; Ashrafian H; Soga T; Pollard PJ. 2013. A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia. Cell Rep 3(5):1440-8. PubMed: 23643539MGI: J:198486
- Albers J; Rajski M; Schonenberger D; Harlander S; Schraml P; von Teichman A; Georgiev S; Wild PJ; Moch H; Krek W; Frew IJ. 2013. Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice. EMBO Mol Med 5(6):949-64. PubMed: 23606570MGI: J:231875
- Baba M; Furihata M; Hong SB; Tessarollo L; Haines DC; Southon E; Patel V; Igarashi P; Alvord WG; Leighty R; Yao M; Bernardo M; Ileva L; Choyke P; Warren MB; Zbar B; Linehan WM; Schmidt LS. 2008. Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst 100(2):140-54. PubMed: 18182616MGI: J:130978
- Bardella C; El-Bahrawy M; Frizzell N; Adam J; Ternette N; Hatipoglu E; Howarth K; O'Flaherty L; Roberts I; Turner G; Taylor J; Giaslakiotis K; Macaulay VM; Harris AL; Chandra A; Lehtonen HJ; Launonen V; Aaltonen LA; Pugh CW; Mihai R; Trudgian D; Kessler B; Baynes JW; Ratcliffe PJ; Tomlinson IP; Pollard PJ. 2011. Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status. J Pathol 225(1):4-11. PubMed: 21630274MGI: J:175252
- Bartram MP; Dafinger C; Habbig S; Benzing T; Schermer B; Muller RU. 2015. Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation. BMC Nephrol 16:55. PubMed: 25881298MGI: J:233486
- Bhagat TD; Zou Y; Huang S; Park J; Palmer MB; Hu C; Li W; Shenoy N; Giricz O; Choudhary G; Yu Y; Ko YA; Izquierdo MC; Park AS; Vallumsetla N; Laurence R; Lopez R; Suzuki M; Pullman J; Kaner J; Gartrell B; Hakimi AA; Greally JM; Patel B; Benhadji K; Pradhan K; Verma A; Susztak K. 2017. Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer. J Biol Chem 292(3):837-846. PubMed: 27909050MGI: J:239239
- Breiderhoff T; Himmerkus N; Stuiver M; Mutig K; Will C; Meij IC; Bachmann S; Bleich M; Willnow TE; Muller D. 2012. Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis. Proc Natl Acad Sci U S A 109(35):14241-6. PubMed: 22891322MGI: J:188580
- Cai Y; Fedeles SV; Dong K; Anyatonwu G; Onoe T; Mitobe M; Gao JD; Okuhara D; Tian X; Gallagher AR; Tang Z; Xie X; Lalioti MD; Lee AH; Ehrlich BE; Somlo S. 2014. Altered trafficking and stability of polycystins underlie polycystic kidney disease. J Clin Invest 124(12):5129-44. PubMed: 25365220MGI: J:219409
- Calcagni A; Kors L; Verschuren E; De Cegli R; Zampelli N; Nusco E; Confalonieri S; Bertalot G; Pece S; Settembre C; Malouf GG; Leemans JC; de Heer E; Salvatore M; Peters DJ; Di Fiore PP; Ballabio A. 2016. Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling. Elife 5:. PubMed: 27668431MGI: J:238095
- Chen J; Futami K; Petillo D; Peng J; Wang P; Knol J; Li Y; Khoo SK; Huang D; Qian CN; Zhao P; Dykyma K; Zhang R; Cao B; Yang XJ; Furge K; Williams BO; Teh BT. 2008. Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia. PLoS One 3(10):e3581. PubMed: 18974783MGI: J:143922
- Chen L; Zhou X; Fan LX; Yao Y; Swenson-Fields KI; Gadjeva M; Wallace DP; Peters DJ; Yu A; Grantham JJ; Li X. 2015. Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease. J Clin Invest 125(6):2399-412. PubMed: 25961459MGI: J:222949
- Choi SY; Chacon-Heszele MF; Huang L; McKenna S; Wilson FP; Zuo X; Lipschutz JH. 2013. Cdc42 deficiency causes ciliary abnormalities and cystic kidneys. J Am Soc Nephrol 24(9):1435-50. PubMed: 23766535MGI: J:226739
- Chu PY; Cheng CJ; Wu YC; Fang YW; Chau T; Uchida S; Sasaki S; Yang SS; Lin SH. 2013. SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation. PLoS One 8(9):e72969. PubMed: 24039833MGI: J:207559
- Cognard N; Scerbo MJ; Obringer C; Yu X; Costa F; Haser E; Le D; Stoetzel C; Roux MJ; Moulin B; Dollfus H; Marion V. 2015. Comparing the Bbs10 complete knockout phenotype with a specific renal epithelial knockout one highlights the link between renal defects and systemic inactivation in mice. Cilia 4:10. PubMed: 26273430MGI: J:227230
- Couillard M; Trudel M. 2009. C-myc as a modulator of renal stem/progenitor cell population. Dev Dyn 238(2):405-14. PubMed: 19161241MGI: J:144178
- Faria D; Rock JR; Romao AM; Schweda F; Bandulik S; Witzgall R; Schlatter E; Heitzmann D; Pavenstadt H; Herrmann E; Kunzelmann K; Schreiber R. 2014. The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function. Kidney Int 85(6):1369-81. PubMed: 24476694MGI: J:210158
- Fedeles SV; Tian X; Gallagher AR; Mitobe M; Nishio S; Lee SH; Cai Y; Geng L; Crews CM; Somlo S. 2011. A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nat Genet 43(7):639-47. PubMed: 21685914MGI: J:188763
- Fischer E; Legue E; Doyen A; Nato F; Nicolas JF; Torres V; Yaniv M; Pontoglio M. 2006. Defective planar cell polarity in polycystic kidney disease. Nat Genet 38(1):21-3. PubMed: 16341222MGI: J:134544
- Fogelgren B; Polgar N; Lui VH; Lee AJ; Tamashiro KK; Napoli JA; Walton CB; Zuo X; Lipschutz JH. 2015. Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions. PLoS One 10(6):e0129346. PubMed: 26046524MGI: J:226950
- Frew IJ; Minola A; Georgiev S; Hitz M; Moch H; Richard S; Vortmeyer AO; Krek W. 2008. Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia. Mol Cell Biol 28(14):4536-48. PubMed: 18474617MGI: J:137442
- Frew IJ; Thoma CR; Georgiev S; Minola A; Hitz M; Montani M; Moch H; Krek W. 2008. pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation. EMBO J 27(12):1747-57. PubMed: 18497742MGI: J:137073
- Gamba G. 2014. Regulation of NKCC2 activity by SPAK truncated isoforms. Am J Physiol Renal Physiol 306(1):F49-50. PubMed: 24173353MGI: J:205045
- Gao M; Cao R; Du S; Jia X; Zheng S; Huang S; Han Q; Liu J; Zhang X; Miao Y; Kang J; Gustafsson JA; Guan Y. 2015. Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts. Proc Natl Acad Sci U S A 112(27):8397-402. PubMed: 26100911MGI: J:223736
- Genetic Resource Science at The Jackson Laboratory. 2013. Expression/Specificity Patterns of Cre Alleles, 2013 Direct Data Submission from Genetic Resource Science :. MGI: J:193672
- Goodwin JE; Zhang J; Velazquez H; Geller DS. 2010. The glucocorticoid receptor in the distal nephron is not necessary for the development or maintenance of dexamethasone-induced hypertension. Biochem Biophys Res Commun 394(2):266-71. PubMed: 20188070MGI: J:158817
- Grahammer F; Haenisch N; Steinhardt F; Sander L; Roerden M; Arnold F; Cordts T; Wanner N; Reichardt W; Kerjaschki D; Ruegg MA; Hall MN; Moulin P; Busch H; Boerries M; Walz G; Artunc F; Huber TB. 2014. mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci U S A 111(27):E2817-26. PubMed: 24958889MGI: J:212166
- Grahammer F; Nesterov V; Ahmed A; Steinhardt F; Sandner L; Arnold F; Cordts T; Negrea S; Bertog M; Ruegg MA; Hall MN; Walz G; Korbmacher C; Artunc F; Huber TB. 2016. mTORC2 critically regulates renal potassium handling. J Clin Invest 126(5):1773-82. PubMed: 27043284MGI: J:234958
- Grande MT; Sanchez-Laorden B; Lopez-Blau C; De Frutos CA; Boutet A; Arevalo M; Rowe RG; Weiss SJ; Lopez-Novoa JM; Nieto MA. 2015. Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease. Nat Med 21(9):989-97. PubMed: 26236989MGI: J:228824
- Gresh L; Fischer E; Reimann A; Tanguy M; Garbay S; Shao X; Hiesberger T; Fiette L; Igarashi P; Yaniv M; Pontoglio M. 2004. A transcriptional network in polycystic kidney disease. EMBO J 23(7):1657-68. PubMed: 15029248MGI: J:131271
- Guinot A; Lehmann H; Wild PJ; Frew IJ. 2016. Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions. J Pathol 239(3):365-73. PubMed: 27126173MGI: J:241555
- Guitart AV; Panagopoulou TI; Villacreces A; Vukovic M; Sepulveda C; Allen L; Carter RN; van de Lagemaat LN; Morgan M; Giles P; Sas Z; Gonzalez MV; Lawson H; Paris J; Edwards-Hicks J; Schaak K; Subramani C; Gezer D; Armesilla-Diaz A; Wills J; Easterbrook A; Coman D; So CW; O'Carroll D; Vernimmen D; Rodrigues NP; Pollard PJ; Morton NM; Finch A; Kranc KR. 2017. Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions. J Exp Med 214(3):719-735. PubMed: 28202494MGI: J:241535
- Hakim S; Dyson JM; Feeney SJ; Davies EM; Sriratana A; Koenig MN; Plotnikova OV; Smyth IM; Ricardo SD; Hobbs RM; Mitchell CA. 2016. Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling. Hum Mol Genet 25(11):2295-2313. PubMed: 27056978MGI: J:236703
- Hasumi H; Baba M; Hasumi Y; Huang Y; Oh H; Hughes RM; Klein ME; Takikita S; Nagashima K; Schmidt LS; Linehan WM. 2012. Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J Natl Cancer Inst 104(22):1750-64. PubMed: 23150719MGI: J:192024
- Hasumi H; Baba M; Hasumi Y; Lang M; Huang Y; Oh HF; Matsuo M; Merino MJ; Yao M; Ito Y; Furuya M; Iribe Y; Kodama T; Southon E; Tessarollo L; Nagashima K; Haines DC; Linehan WM; Schmidt LS. 2015. Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn. Proc Natl Acad Sci U S A 112(13):E1624-31. PubMed: 25775561MGI: J:220672
- Hell MP; Duda M; Weber TC; Moch H; Krek W. 2014. Tumor Suppressor VHL Functions in the Control of Mitotic Fidelity. Cancer Res 74(9):2422-31. PubMed: 24362914MGI: J:209063
- Hell MP; Thoma CR; Fankhauser N; Christinat Y; Weber TC; Krek W. 2014. miR-28-5p Promotes Chromosomal Instability in VHL-Associated Cancers by Inhibiting Mad2 Translation. Cancer Res 74(9):2432-43. PubMed: 24491803MGI: J:209149
- Hong SB; Oh H; Valera VA; Baba M; Schmidt LS; Linehan WM. 2010. Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization. PLoS One 5(12):e15793. PubMed: 21209915MGI: J:196261
- Ikenberg K; Valtcheva N; Brandt S; Zhong Q; Wong CE; Noske A; Rechsteiner M; Rueschoff JH; Caduff R; Dellas A; Obermann E; Fink D; Fuchs T; Krek W; Moch H; Frew IJ; Wild PJ. 2014. KPNA2 is overexpressed in human and mouse endometrial cancers and promotes cellular proliferation. J Pathol 234(2):239-52. PubMed: 24930886MGI: J:214850
- Joshi A; Miller C Jr; Baker SJ; Ellenson LH. 2015. Activated Mutant p110alpha Causes Endometrial Carcinoma in the Setting of Biallelic Pten Deletion. Am J Pathol 185(4):1104-13. PubMed: 25698082MGI: J:220252
- Kai T; Tsukamoto Y; Hijiya N; Tokunaga A; Nakada C; Uchida T; Daa T; Iha H; Takahashi M; Nomura T; Sato F; Mimata H; Ikawa M; Seto M; Matsuura K; Moriyama M. 2016. Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway. J Pathol 239(1):97-108. PubMed: 26913567MGI: J:241188
- Kaminski MM; Tosic J; Kresbach C; Engel H; Klockenbusch J; Muller AL; Pichler R; Grahammer F; Kretz O; Huber TB; Walz G; Arnold SJ; Lienkamp SS. 2016. Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors. Nat Cell Biol 18(12):1269-1280. PubMed: 27820600MGI: J:238554
- Karner CM; Chirumamilla R; Aoki S; Igarashi P; Wallingford JB; Carroll TJ. 2009. Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet 41(7):793-9. PubMed: 19543268MGI: J:151498
- Karner CM; Das A; Ma Z; Self M; Chen C; Lum L; Oliver G; Carroll TJ. 2011. Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development 138(7):1247-57. PubMed: 21350016MGI: J:171512
- Kim D; Wang M; Cai Q; Brooks H; Dressler GR. 2007. Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia. J Am Soc Nephrol 18(5):1458-65. PubMed: 17429055MGI: J:148599
- Kim HY; Verlander JW; Bishop JM; Cain BD; Han KH; Igarashi P; Lee HW; Handlogten ME; Weiner ID. 2009. Basolateral expression of the ammonia transporter family member Rh C glycoprotein in the mouse kidney. Am J Physiol Renal Physiol 296(3):F543-55. PubMed: 19129254MGI: J:145704
- Landrette SF; Cornett JC; Ni TK; Bosenberg MW; Xu T. 2011. piggyBac transposon somatic mutagenesis with an activated reporter and tracker (PB-SMART) for genetic screens in mice. PLoS One 6(10):e26650. PubMed: 22039523MGI: J:179725
- Lee HW; Verlander JW; Bishop JM; Igarashi P; Handlogten ME; Weiner ID. 2009. Collecting duct-specific Rh C glycoprotein deletion alters basal and acidosis-stimulated renal ammonia excretion. Am J Physiol Renal Physiol 296(6):F1364-75. PubMed: 19321595MGI: J:196636
- Lee HW; Verlander JW; Handlogten ME; Han KH; Weiner ID. 2014. Effect of collecting duct-specific deletion of both Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) on renal response to metabolic acidosis. Am J Physiol Renal Physiol 306(4):F389-400. PubMed: 24338819MGI: J:206295
- Lepoutre-Lussey C; Thibault C; Buffet A; Morin A; Badoual C; Benit P; Rustin P; Ottolenghi C; Janin M; Castro-Vega LJ; Trapman J; Gimenez-Roqueplo AP; Favier J. 2016. From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma. Mol Cell Endocrinol 421:40-8. PubMed: 26123588MGI: J:236514
- Li L; Black R; Ma Z; Yang Q; Wang A; Lin F. 2012. Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. Am J Physiol Renal Physiol 302(1):F9-F19. PubMed: 21937606MGI: J:180011
- Li L; Garikepati RM; Tsukerman S; Tiwari S; Ecelbarger CM. 2012. Salt sensitivity of nitric oxide generation and blood pressure in mice with targeted knockout of the insulin receptor from the renal tubule. Am J Physiol Regul Integr Comp Physiol 303(5):R505-12. PubMed: 22814664MGI: J:191337
- Li L; Zepeda-Orozco D; Black R; Lin F. 2010. Autophagy is a component of epithelial cell fate in obstructive uropathy. Am J Pathol 176(4):1767-78. PubMed: 20150430MGI: J:158607
- Li Y; Tian X; Ma M; Jerman S; Kong S; Somlo S; Sun Z. 2016. Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts. J Am Soc Nephrol 27(12):3628-3638. PubMed: 27153923MGI: J:240795
- Liang L; Li L; Tian J; Lee SO; Dang Q; Huang CK; Yeh S; Erturk E; Bushinsky D; Chang LS; He D; Chang C. 2014. Androgen receptor enhances kidney stone-CaOx crystal formation via modulation of oxalate biosynthesis & oxidative stress. Mol Endocrinol 28(8):1291-303. PubMed: 24956378MGI: J:216237
- Lin F; Hiesberger T; Cordes K; Sinclair AM; Goldstein LS; Somlo S; Igarashi P. 2003. Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci U S A 100(9):5286-91. PubMed: 12672950MGI: J:83293
- Lin SH; Yu IS; Jiang ST; Lin SW; Chu P; Chen A; Sytwu HK; Sohara E; Uchida S; Sasaki S; Yang SS. 2011. Impaired phosphorylation of Na+-K+-2Cl- cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A 108(42):17538-43. PubMed: 21972418MGI: J:177443
- Ma M; Tian X; Igarashi P; Pazour GJ; Somlo S. 2013. Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease. Nat Genet 45(9):1004-12. PubMed: 23892607MGI: J:205308
- Ma Z; Gong Y; Patel V; Karner CM; Fischer E; Hiesberger T; Carroll TJ; Pontoglio M; Igarashi P. 2007. Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3. Proc Natl Acad Sci U S A 104(51):20386-91. PubMed: 18077349MGI: J:130583
- Meng XM; Huang XR; Chung AC; Qin W; Shao X; Igarashi P; Ju W; Bottinger EP; Lan HY. 2010. Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis. J Am Soc Nephrol 21(9):1477-87. PubMed: 20595680MGI: J:185921
- Meng XM; Huang XR; Xiao J; Chen HY; Zhong X; Chung AC; Lan HY. 2012. Diverse roles of TGF-beta receptor II in renal fibrosis and inflammation in vivo and in vitro. J Pathol 227(2):175-88. PubMed: 22190171MGI: J:183441
- Meng XM; Huang XR; Xiao J; Chung AC; Qin W; Chen HY; Lan HY. 2012. Disruption of Smad4 impairs TGF-beta/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro. Kidney Int 81(3):266-79. PubMed: 22048127MGI: J:196554
- Milatz S; Himmerkus N; Wulfmeyer VC; Drewell H; Mutig K; Hou J; Breiderhoff T; Muller D; Fromm M; Bleich M; Gunzel D. 2017. Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport. Proc Natl Acad Sci U S A 114(2):E219-E227. PubMed: 28028216MGI: J:239545
- Olauson H; Lindberg K; Amin R; Jia T; Wernerson A; Andersson G; Larsson TE. 2012. Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism. J Am Soc Nephrol 23(10):1641-51. PubMed: 22878961MGI: J:201719
- Paragas N; Kulkarni R; Werth M; Schmidt-Ott KM; Forster C; Deng R; Zhang Q; Singer E; Klose AD; Shen TH; Francis KP; Ray S; Vijayakumar S; Seward S; Bovino ME; Xu K; Takabe Y; Amaral FE; Mohan S; Wax R; Corbin K; Sanna-Cherchi S; Mori K; Johnson L; Nickolas T; D'Agati V; Lin CS; Qiu A; Al-Awqati Q; Ratner AJ; Barasch J. 2014. alpha-Intercalated cells defend the urinary system from bacterial infection. J Clin Invest 124(7):2963-76. PubMed: 24937428MGI: J:213786
- Parajuli N; Macmillan-Crow LA. 2013. Role of reduced manganese superoxide dismutase in ischemia-reperfusion injury: a possible trigger for autophagy and mitochondrial biogenesis? Am J Physiol Renal Physiol 304(3):F257-67. PubMed: 23195678MGI: J:192570
- Parajuli N; Marine A; Simmons S; Saba H; Mitchell T; Shimizu T; Shirasawa T; Macmillan-Crow LA. 2011. Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse. Free Radic Biol Med 51(2):406-16. PubMed: 21571061MGI: J:174099
- Patel V; Williams D; Hajarnis S; Hunter R; Pontoglio M; Somlo S; Igarashi P. 2013. miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. Proc Natl Acad Sci U S A 110(26):10765-70. PubMed: 23759744MGI: J:197969
- Polgar N; Lee AJ; Lui VH; Napoli JA; Fogelgren B. 2015. The exocyst gene Sec10 regulates renal epithelial monolayer homeostasis and apoptotic sensitivity. Am J Physiol Cell Physiol 309(3):C190-201. PubMed: 26040895MGI: J:226951
- Pollard PJ; Spencer-Dene B; Shukla D; Howarth K; Nye E; El-Bahrawy M; Deheragoda M; Joannou M; McDonald S; Martin A; Igarashi P; Varsani-Brown S; Rosewell I; Poulsom R; Maxwell P; Stamp GW; Tomlinson IP. 2007. Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell 11(4):311-9. PubMed: 17418408MGI: J:120969
- Qian CN; Furge KA; Knol J; Huang D; Chen J; Dykema KJ; Kort EJ; Massie A; Khoo SK; Vanden Beldt K; Resau JH; Anema J; Kahnoski RJ; Morreau H; Camparo P; Comperat E; Sibony M; Denoux Y; Molinie V; Vieillefond A; Eng C; Williams BO; Teh BT. 2009. Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models. Cancer Res 69(21):8256-64. PubMed: 19843858MGI: J:153952
- Qian CN; Knol J; Igarashi P; Lin F; Zylstra U; Teh BT; Williams BO. 2005. Cystic Renal Neoplasia Following Conditional Inactivation of Apc in Mouse Renal Tubular Epithelium. J Biol Chem 280(5):3938-3945. PubMed: 15550389MGI: J:95502
- Rowe I; Chiaravalli M; Mannella V; Ulisse V; Quilici G; Pema M; Song XW; Xu H; Mari S; Qian F; Pei Y; Musco G; Boletta A. 2013. Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy. Nat Med 19(4):488-93. PubMed: 23524344MGI: J:198374
- Saifudeen Z; Dipp S; Stefkova J; Yao X; Lookabaugh S; El-Dahr SS. 2009. p53 regulates metanephric development. J Am Soc Nephrol 20(11):2328-37. PubMed: 19729440MGI: J:166316
- Schell C; Kretz O; Liang W; Kiefer B; Schneider S; Sellung D; Bork T; Leiber C; Ruegg MA; Mallidis C; Schlatt S; Mayerhofer A; Huber TB; Grahammer F. 2016. The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility. Am J Pathol 186(2):324-36. PubMed: 26683665MGI: J:229682
- Schonenberger D; Harlander S; Rajski M; Jacobs RA; Lundby AK; Adlesic M; Hejhal T; Wild PJ; Lundby C; Frew IJ. 2016. Formation of Renal Cysts and Tumors in Vhl/Trp53-Deficient Mice Requires HIF1alpha and HIF2alpha. Cancer Res 76(7):2025-36. PubMed: 26759234MGI: J:231634
- Seixas C; Choi SY; Polgar N; Umberger NL; East MP; Zuo X; Moreiras H; Ghossoub R; Benmerah A; Kahn RA; Fogelgren B; Caspary T; Lipschutz JH; Barral DC. 2016. Arl13b and the exocyst interact synergistically in ciliogenesis. Mol Biol Cell 27(2):308-20. PubMed: 26582389MGI: J:234047
- Shibazaki S; Yu Z; Nishio S; Tian X; Thomson RB; Mitobe M; Louvi A; Velazquez H; Ishibe S; Cantley LG; Igarashi P; Somlo S. 2008. Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum Mol Genet 17(11):1505-16. PubMed: 18263604MGI: J:135301
- Takiar V; Nishio S; Seo-Mayer P; King JD Jr; Li H; Zhang L; Karihaloo A; Hallows KR; Somlo S; Caplan MJ. 2011. Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc Natl Acad Sci U S A 108(6):2462-7. PubMed: 21262823MGI: J:169102
- Tiwari S; Sharma N; Gill PS; Igarashi P; Kahn CR; Wade JB; Ecelbarger CM. 2008. Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor. Proc Natl Acad Sci U S A 105(17):6469-74. PubMed: 18424559MGI: J:134541
- Urbach A; Yermalovich A; Zhang J; Spina CS; Zhu H; Perez-Atayde AR; Shukrun R; Charlton J; Sebire N; Mifsud W; Dekel B; Pritchard-Jones K; Daley GQ. 2014. Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev 28(9):971-82. PubMed: 24732380MGI: J:211179
- Wild PJ; Ikenberg K; Fuchs TJ; Rechsteiner M; Georgiev S; Fankhauser N; Noske A; Roessle M; Caduff R; Dellas A; Fink D; Moch H; Krek W; Frew IJ. 2012. p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans. EMBO Mol Med 4(8):808-24. PubMed: 22678923MGI: J:215149
- Wodarczyk C; Distefano G; Rowe I; Gaetani M; Bricoli B; Muorah M; Spitaleri A; Mannella V; Ricchiuto P; Pema M; Castelli M; Casanova AE; Mollica L; Banzi M; Boca M; Antignac C; Saunier S; Musco G; Boletta A. 2010. Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals. PLoS One 5(9):e12719. PubMed: 20856870MGI: J:165121
- Zhou D; Li Y; Lin L; Zhou L; Igarashi P; Liu Y. 2012. Tubule-specific ablation of endogenous beta-catenin aggravates acute kidney injury in mice. Kidney Int 82(5):537-47. PubMed: 22622501MGI: J:198173
- Zhou D; Tan RJ; Zhou L; Li Y; Liu Y. 2013. Kidney tubular beta-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication. Sci Rep 3:1878. PubMed: 23698793MGI: J:207805
- Zhou H; Gao J; Zhou L; Li X; Li W; Li X; Xia Y; Yang B. 2012. Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models. Am J Physiol Renal Physiol 302(10):F1234-42. PubMed: 22338085MGI: J:184731
- Zhou X; Fan LX; Li K; Ramchandran R; Calvet JP; Li X. 2014. SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. Hum Mol Genet 23(6):1644-55. PubMed: 24203696MGI: J:206980
- Zhou X; Fan LX; Sweeney WE Jr; Denu JM; Avner ED; Li X. 2013. Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. J Clin Invest 123(7):3084-98. PubMed: 23778143MGI: J:201423