These targeted mutation mice lack exon 3 of the Bim (<i>Bcl2l11</i>, BCL2-like 11 (apoptosis facilitator)) gene.  Alternative splicing to include exon 3 is required for expression of the BimEL isoform, lacking in these mice.  Other isoforms, including BimL and BimS, are expressed however.  These mice represent a model for the analysis of BimEL loss-of-function. 

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These targeted mutation mice lack exon 3 of the Bim (<i>Bcl2l11</i>, BCL2-like 11 (apoptosis facilitator)) gene as well as expression of the BimEL isoform.  Other isoforms, including BimL and BimS, are expressed.  These mice represent a model for the analysis of BimEL loss-of-function.

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