This NOD/MrkTac bicongenic strain carries a C57BL/6 derived genome on Chr. 3 that contains Idd3/17/10/18 and C57BL/10 derived genome on Chr. 4 containing Idd9.1, 9.2, 9.3. Unlike the parental strains, known to have low frequency diabetes, no diabetes and almost no insulitis has been detected by 12 months of age in this strain. However, at 9-11 months of age 50% of the females and 25% of the males develop autoimmune liver disease. Histological evaluation showed biliary cyst formation and obstruction which progresses with age and lymphocytic infiltrates adjacent to the cyst walls were observed. Further histological studies indicate that 44% of 8-week-old mice had early cyst formation and lymphocytic infiltrates and at 30 weeks of age 90% of the animals evaluated had cyst formation and lymphocytic infiltration, Koarada et al, 2004. The donating investigator has communicated that recent findings indicate the C57BL/6 genetic contamination on chromosome 1 is necessary for development of the autoimmune liver disease. This strain may be useful for identifying Idd genes within the congenic regions and provides a spontaneous mouse model for autoimmune biliary disease (ABD) that models human primary biliary cirrhosis (hPBC). 
 Of note, when made public in 2009 this strain nomenclature was originally incorrect - listing D4Mit142 instead of D4Mit42. This created confusion and difficulty in identifying presence/absence of the C57BL/10SnJ-derived region on chromosome 4. We have confirmed the correct chromosome 4 structure, in the correct interval, which is D4Mit114-D4Mit42. The strain nomenclature has now been corrected [June 2023]. The C57BL/6-derived chromosome 3 segment was never in question. See Development section for additional information and the genotyping assays we use for this.

This strain is currently unavailable due to replenishing of cryopreserved stocks and undergoing GQC evaluation. Interested customers who register interest will be contacted when the strain is again available. This chromosome 3 and 4, NOD/MrkTac bicongenic strain may be useful for identifying Idd genes within the congenic regions and provides a spontaneous mouse model for autoimmune biliary disease (ABD) that models human primary biliary cirrhosis (hPBC).

Not available for ordering yet; register interest to be informed of changes in availability or <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support/technical-support/contact-technical-support-form">Contact Technical Support</a> for more information.