These mice possess loxP sites on either side of exons 7 and 8 of Grk5 (G protein-coupled receptor kinase 5). Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When bred to mice with a cre recombinase gene, exons 7 and 8 of the targeted gene are deleted in the cre-expressing tissues in the offspring mice. The floxed allele appears to be fully functional and expresses normal levels of GRK5 protein. 

 When bred to 	
B6.FVB-Tg(Myh6-cre)2182Mds/J mice (Stock No. <a href="https://www.jax.org/strain/011038">011038</a>) expressing Cre recombinase in cardiac muscle cells, offspring exhibit protection from cardiac hypertrophy following transverse aortic constriction.

These mice carry a floxed allele of Grk5. When bred to mice with a cre recombinase gene, exons 7 and 8 of the targeted gene are deleted in the cre-expressing tissues in the offspring mice. This strain may be useful in mechanistic studies of muscarinic receptors and Alzheimer's disease.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.