Heterozygotes have a slight increase in electroconvulsion over wild-type controls and 90% of homozygotes on this 129S1 background die before birth.  In electroconvulsion tests some homozygotes were found to bypass the minimal clonic seizure endpoint and proceed directly to tonic hindlimb extension.  On the C57BL/6J background (stock #010916) no homozygotes were found to survive to birth.  In addition to the increased seizure phenotype, homozygotes on this 129S1 background have a slightly diluted coat color.

Heterozygous mice show an increase in electroconvulsion, and 90% of homozygous mice die before birth.

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