These mice possess loxP sites on either side of exons 2-7 of the Flna (filamin, alpha) gene. Mice that are homozygous/hemizygous for this X-linked allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When bred to mice expressing cre recombinase, the floxed exons are deleted in the tissues expressing cre in the offspring. 

 When bred to a strain expressing Cre recombinase in midbrain/dorsal spinal cord (see Stock No. <a href="https://www.jax.org/strain/009107">009107</a> for example), this mutant mouse strain may be useful in studies of vascular development.

These mice harbor a conditional knockout allele of the Flna gene. When bred to mice expressing cre recombinase, the floxed exons are deleted in the tissues expressing cre in the offspring. This strain may be useful in mechanistic studies of neuronal and cardiovascular development.

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