mammalian phenotype

• behavior/neurological phenotype
  • Normal - male homozygotes displayed normal locomotor activity in the elevated plus-maze test, and in a novel environment
  (MGI Ref ID J:61485)
  • Normal - female homozygotes showed normal baseline anxiety levels, stress-induced anxiety, and locomotor activity relative to wild-type
  (MGI Ref ID J:61485)
  • Normal - female homozygotes showed normal behavior in the dark-light emergence task, open-field and acute locomotor activity test
  (MGI Ref ID J:61485)
  • Normal - male and female homozygotes showed normal baseline feeding and body weight gain
  (MGI Ref ID J:61485)
  • Normal - baseline anxiety of female wild-type and homozygous mice did not change with regard to estrous cycle phase
  (MGI Ref ID J:61485)

• hearing/vestibular/ear phenotype
  • Normal - no auditory or orientational deficits
  (MGI Ref ID J:61485)

• homeostasis/metabolism phenotype
  • Normal - the increased POMC1 (ACTH) and corticosterone levels produced by male or female homozygotes did not differ from the values obtained for matched wild-type controls
  (MGI Ref ID J:61485)
  • Normal - homozygotes displayed a normal activation of the HPA axis in response to 10 minutes of physical restraint stress
  (MGI Ref ID J:61485)

• vision/eye phenotype
  • Normal - no visual deficits
  (MGI Ref ID J:61485)

behavior/neurological phenotype

• increased anxiety-related response
  • all genotypes showed a similar level and distribution of Fos protein after exposure to the pus-maze regardless of gender
  (MGI Ref ID J:61485)
  • in the elevated plus-maze, homozygous males appeared to be more anxious than wild-type males
  (MGI Ref ID J:61485)
  • a single 5-min exposure to the elevated plus-maze resulted in a sustained elevation of phosphorylated Creb and widespread Fos production
  (MGI Ref ID J:61485)
  • the basolateral amygdala
  (MGI Ref ID J:61485)
  • in the open-field, homozygotes were explorative and did not differ from wild-type in traveled distance and time spent in the peripheral zones; however, homozygotes showed increased center region activity
  (MGI Ref ID J:61485)
  • the levels of pCreb were lower in specific brain regions of male, but not female, homozygotes compared with wild-type controls: these regions included the cingulate cortex, the bed nucleus of the stria terminalis, the ventromedial hypothalamic nucleus and the basolateral amygdala
  (MGI Ref ID J:61485)

cardiovascular system phenotype

• abnormal vascular permeability
  • homozygotes of both genders exhibited increased edema formation in response to thermal injury relative to wild-type
  (MGI Ref ID J:61485)

behavior/neurological phenotype

• increased anxiety-related response
  • in the elevated plus-maze, heterozygous males appeared to be more anxious than wild-type males
  (MGI Ref ID J:61485)
  • in the dark-light emergence and open-field tests, the anxiety level of heterozygotes was between that of homozygous null and wild-type mice
  (MGI Ref ID J:61485)
  • in the elevated plus-maze, the anxious behavior of heterozygotes was indistinguishable from that of homozygous null mice
  (MGI Ref ID J:61485)

mammalian phenotype

• homeostasis/metabolism phenotype
  • Normal - the increased POMC1 (ACTH) and corticosterone levels produced by male or female heterozygotes did not differ from the values obtained for matched wild-type controls
  (MGI Ref ID J:61485)
  • Normal - heterozygotes displayed a normal activation of the HPA axis in response to 10 minutes of physical restraint stress
  (MGI Ref ID J:61485)

• behavior/neurological phenotype
  • Normal - male heterozygotes displayed normal locomotor activity in the elevated plus-maze test, and in a novel environment
  (MGI Ref ID J:61485)
  • Normal - female heterozygotes showed normal baseline anxiety levels, stress-induced anxiety, and locomotor activity relative to wild-type
  (MGI Ref ID J:61485)
  • Normal - female heterozygotes showed normal behavior in the dark-light emergence task, open-field and acute locomotor activity test
  (MGI Ref ID J:61485)
  • Normal - baseline anxiety of female wild-type and heterozygous mice did not change with regard to estrous cycle phase
  (MGI Ref ID J:61485)