Mice that are homozygous for the targeted mutation are viable, fertile, and normal in size.  No gene product (mRNA) is detected by Northern blot analysis of homozygous primary embryonic fibroblasts.  Mice that are homozygous for this targeted allele lack type I IFN receptor function, exhibit enhanced osteoclastogenesis with decreased bone density, and impaired response to protozoan parasite (Leishmania) infection.  NK cell mediated tumor regression does not occur in homozygotes in response to B16 melanoma tumor implant model. Mouse mutants involving this gene have been used in studies of Zika virus pathogenesis. 

Notice regarding distribution of this strain.

Mice homozygous for this <i>Ifnar1</i> knock-out mutation are more susceptible to viral infection, have an abnormal NK antitumor response, and reduced bone mass.  This mutant mouse strain may be useful in studies of immunological responses to infection, and bone homeostasis. Mouse mutants involving this gene have been used in studies of Zika virus pathogenesis. Note: these mice carry the same allele as 'A129' mice, although on a congenic C57BL/6, not 129, genetic background.






This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. <b>For additional information and to purchase, please visit the MMRRC site.</b>