Similar to other Ush1c mutants, these homozygotes are deaf at an early age, display circling and head shaking behavior, and provide a model for autosomal recessive nonsyndromic deafness 18A and Usher syndrome type 1C
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous (Not Specified) | Ush1c | USH1 protein network component harmonin |
Homozygotes display circling and side-to-side head shaking behavior and complete deafness at one month of age. A heterozygote was also found to have slightly elevated ABR thresholds at 32kHz. Homozygotes fail to orient in water to swim and instead roll underwater.
The deaf circler 4 Jackson remutation arose spontaneously on the 129P3/J inbred background at The Jackson Laboratory in 2006 and was maintained coisogenic on this background by sibling intercrossing and in 2011 sperm was cryopreserved from homozygous males at generation +F12. The test cryo-recovery was performed using C57BL/6J due to the reduced availability of 129P3/J females. Thus, standard cryo-recovery is scheduled to use C57BL/6J. To retain coisogenicity, cryo-recovery would need to use 129P3/J oocytes, but this is only possible with an increased fee. Please inquire.
Allele Name | deaf circler 4 Jackson |
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Allele Type | Spontaneous (Not Specified) |
Allele Synonym(s) | |
Gene Symbol and Name | Ush1c, USH1 protein network component harmonin |
Gene Synonym(s) | |
Strain of Origin | 129P3/J |
Chromosome | 7 |
Molecular Note | This spontaneous mutation was proven to be an allele of Ush1c by failed complementation with the dfcr allele. |
Because of the risk that female homozygotes may trample their pups it is best to maintain this strain with heterozygous female breeders.
When using the B6;129P3-Ush1cdfcr-4J/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #010749 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Please inquire |
Frozen Mouse Embryo | B6;129P3-Ush1c<dfcr-4J>/J | $2595.00 |
Frozen Mouse Embryo | B6;129P3-Ush1c<dfcr-4J>/J | $2595.00 |
Frozen Mouse Embryo | B6;129P3-Ush1c<dfcr-4J>/J | $3373.50 |
Frozen Mouse Embryo | B6;129P3-Ush1c<dfcr-4J>/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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