Homozygous mutants exhibit head tilting and hearing loss.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Otog | otogelin |
Mice homozygous for the twisted 4 Jackson mutation have a severe head-tilt but do not circle the way other twisted mutants do. In a swim test they swim tilted to one side usually just below the surface of the water. ABR readings show that these mice are severely hearing impaired at wean age and profoundly deaf by 70 days of age. Otoconial deficiencies exist that are likely due to displacement of the otolithic membrane.
The twisted 4 Jackson mutation arose spontaneously on the C57BL/6J inbred background at The Jackson Laboratory in 2006, was backcrossed once to C57BL/6J, and has subsequently been maintained on this background by sibling mating.
Allele Name | twister 4 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Otog, otogelin |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J |
Chromosome | 7 |
Molecular Note | This mutation was proven allelic with the original twister mutation by a noncomplementation test. |
When using the twister 4 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #010747 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for twt-4J |
Frozen Mouse Embryo | C57BL/6J-Otog<twt-4J>/Kjn | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Otog<twt-4J>/Kjn | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Otog<twt-4J>/Kjn | $3373.50 |
Frozen Mouse Embryo | C57BL/6J-Otog<twt-4J>/Kjn | $3373.50 |
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