C57BL/6J-Otog^twt-4J/Kjn

Stock number: 010747
Product name: twister 4 Jackson

Description

Homozygous mutants exhibit head tilting and hearing loss.

Detailed description

Mice homozygous for the twisted 4 Jackson mutation have a severe head-tilt but do not circle the way other twisted mutants do. In a swim test they swim tilted to one side usually just below the surface of the water. ABR readings show that these mice are severely hearing impaired at wean age and profoundly deaf by 70 days of age. Otoconial deficiencies exist that are likely due to displacement of the otolithic membrane.

Development

The twisted 4 Jackson mutation arose spontaneously on the C57BL/6J inbred background at The Jackson Laboratory in 2006, was backcrossed once to C57BL/6J, and has subsequently been maintained on this background by sibling mating.

Allele

Symbol: Otog^twt-4J
Name: twister 4 Jackson
MGI accession ID: MGI:4421285
Generation method: Spontaneous
Marker symbol: Otog
Marker name: otogelin
Marker synonyms: DFNB18B; MLEMP; OTGN
Chromosome: 7
Strain of origin: C57BL/6J
Molecular note: This mutation was proven allelic with the original twister mutation by a noncomplementation test.