This is one of two reciprocal congenic strains generated to characterize the <i>Cdh23</i> variant between CBA/CaJ and C57BL/6J.  This strain has the wild-type allele of cadherin 23 from CBA/CaJ on the C57BL/6J background, resulting in a predominantly C57BL/6J mouse in which age related hearing loss is delayed and less severe compared with normal C57BL/6J mice. Photomicrographs of cochlear surface preparations show that despite no longer carrying the age related hearing loss mutation, this predominantly C57BL/6J strain does have some inner hair cells missing at 18 months of age.

This congenic is valuable in the study of the genetically complex phenotype of age related hearing loss.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

Typically mice are recovered in 12-16 weeks. <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> to place an order or for more information.