This congenic is valuable in the study of the genetically complex phenotype of age related hearing loss.
Dr. Ken Johnson, JAX
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
QTL | Cdh23 | cadherin 23 (otocadherin) |
This is one of two reciprocal congenic strains generated to characterize the Cdh23 variant between CBA/CaJ and C57BL/6J. This strain has the wild-type allele of cadherin 23 from CBA/CaJ on the C57BL/6J background, resulting in a predominantly C57BL/6J mouse in which age related hearing loss is delayed and less severe compared with normal C57BL/6J mice. Photomicrographs of cochlear surface preparations show that despite no longer carrying the age related hearing loss mutation, this predominantly C57BL/6J strain does have some inner hair cells missing at 18 months of age.
The wild-type allele of cadherin 23 was backcrossed from CBA/CaJ onto C57BL/6J for 10 backcross generations, and then bred to homozygosity.
Allele Name | CBA/CaJ |
---|---|
Allele Type | QTL |
Allele Synonym(s) | |
Gene Symbol and Name | Cdh23, cadherin 23 (otocadherin) |
Gene Synonym(s) | |
Strain of Origin | CBA/CaJ |
Chromosome | 10 |
Molecular Note | This is the CBA/CaJ derived sequence for this gene. |
When using the B6.CBACa-Cdh23CBA/CaJ/Kjn mouse strain in a publication, please cite the originating article(s) and include JAX stock #010615 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Cdh23<CBA/CaJ> |
Frozen Mouse Embryo | B6.CBACa-Cdh23<CBA/CaJ>/Kjn | $2595.00 |
Frozen Mouse Embryo | B6.CBACa-Cdh23<CBA/CaJ>/Kjn | $2595.00 |
Frozen Mouse Embryo | B6.CBACa-Cdh23<CBA/CaJ>/Kjn | $3373.50 |
Frozen Mouse Embryo | B6.CBACa-Cdh23<CBA/CaJ>/Kjn | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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