Expression of the full-length mouse <i>Mef2c</i> (myocyte enhancer factor 2C) cDNA is driven by the cardiac-specific alpha myosin heavy chain promoter in this transgenic strain.  A 1.6-fold increase in expression is observed in the heart by Western blotting.  Mice develop a dilated cardiomyopathy and large atrial clots, consistent with a heart failure phenotype and poor ventricular function. 

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Expression of the full-length mouse <i>Mef2c</i> (myocyte enhancer factor 2C) cDNA is driven by the cardiac-specific alpha myosin heavy chain promoter in this transgenic strain.  Mice develop a dilated cardiomyopathy.

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