Expression of the full-length mouse <i>Mef2c</i> (myocyte enhancer factor 2C) cDNA is driven by the cardiac-specific alpha myosin heavy chain promoter in this transgenic strain.  A 1.6-fold increase in expression is observed in the heart by Western blotting.  Mice develop a dilated cardiomyopathy and large atrial clots, consistent with a heart failure phenotype and poor ventricular function. 

Expression of the full-length mouse <i>Mef2c</i> (myocyte enhancer factor 2C) cDNA is driven by the cardiac-specific alpha myosin heavy chain promoter in this transgenic strain.  Mice develop a dilated cardiomyopathy.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.