The mouse Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter drives expression of TGY->AGF mutant mitogen-activated protein kinase 14 (Mapk14). These mice develop severe hypertrophic cardiomyopathy.
Jeffery D. Molkentin, Cincinnati Children's Hospital
Genetic Background | Generation |
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Allele Type |
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Transgenic (Inserted expressed sequence) |
The mouse Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter drives expression of TGY->AGF mutant mitogen-activated protein kinase 14 (Mapk14). These mice develop severe hypertrophic cardiomyopathy. At two months of age, transgenic mice show a significant increase in heart-to-body weight ratios that progresses with age.
The mouse cardiac alpha myosin heavy chain (Myh6) promoter drives expression of TGY->AGF mutant form of mouse dnp38 alpha (Mapk14). The strain was created and maintained on an FVB background by the donating laboratory.
Expressed Gene | Mapk14, mitogen-activated protein kinase 14, mouse, laboratory |
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Site of Expression |
Allele Name | transgene insertion 1, Jeffery D Molkentin |
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Allele Type | Transgenic (Inserted expressed sequence) |
Allele Synonym(s) | dnp38alpha; Tg(dnp38alpha) |
Gene Symbol and Name | Tg(Myh6-Mapk14*)1Jmol, transgene insertion 1, Jeffery D Molkentin |
Gene Synonym(s) | |
Promoter | Myh6, myosin, heavy polypeptide 6, cardiac muscle, alpha, murine, murine |
Expressed Gene | Mapk14, mitogen-activated protein kinase 14, mouse, laboratory |
Strain of Origin | FVB/N |
Chromosome | UN |
Molecular Note | The mouse cardiac alpha myosin heavy chain (Myh6) promoter drives expression of TGY->AGF mutant form of mouse dnp38 alpha (Mapk14). Three lines were generated and one was chosen for further characterization. |
Mutations Made By | Jeffery Molkentin, Cincinnati Children's Hospital |
When maintained in live colonies, hemizygotes may be bred.
When using the FVB-Tg(Myh6-Mapk14*)1Jmol/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #010583 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Hemizygous or Non carrier for Tg(Myh6-Mapk14*)1Jmol/ |
Frozen Mouse Embryo | FVB-Tg(Myh6-Mapk14*)1Jmol/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | FVB-Tg(Myh6-Mapk14*)1Jmol/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | FVB-Tg(Myh6-Mapk14*)1Jmol/J Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | FVB-Tg(Myh6-Mapk14*)1Jmol/J Frozen Embryo | $3373.50 |
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