FVB-Tg(Myh6-Mapk14*)1Jmol/J

Stock number: 010583
Research areas: Cardiovascular Research

Description

The mouse Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter drives expression of TGY->AGF mutant mitogen-activated protein kinase 14 (Mapk14). These mice develop severe hypertrophic cardiomyopathy.

Detailed description

The mouse Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter drives expression of TGY->AGF mutant mitogen-activated protein kinase 14 (Mapk14). These mice develop severe hypertrophic cardiomyopathy. At two months of age, transgenic mice show a significant increase in heart-to-body weight ratios that progresses with age.

Development

The mouse cardiac alpha myosin heavy chain (Myh6) promoter drives expression of TGY->AGF mutant form of mouse dnp38 alpha (Mapk14). The strain was created and maintained on an FVB background by the donating laboratory.

Allele

Symbol: Tg(Myh6-Mapk14*)1Jmol
Name: transgene insertion 1, Jeffery D Molkentin
MGI accession ID: MGI:3851575
Generation method: Transgenic
Attributes: Inserted expressed sequence
Marker symbol: Tg(Myh6-Mapk14*)1Jmol
Marker name: transgene insertion 1, Jeffery D Molkentin
Chromosome: UN
Strain of origin: FVB/N
Expressed genes: Mapk14,mitogen-activated protein kinase 14,mouse, laboratory
Molecular note: The mouse cardiac alpha myosin heavy chain (Myh6) promoter drives expression of TGY->AGF mutant form of mouse dnp38 alpha (Mapk14). Three lines were generated and one was chosen for further characterization.